Transplant Immunology Quiz

Which of the following responses is the type of allograft rejection associated with vascular and parenchymal injury with lymphocyte infiltrates?

• Hyperacute rejection

• Acute cellular rejection

• Acute humoral rejection

• Chronic rejection

Antigen receptors on T lymphocytes bind HLA class II + peptide complexes with the help of which accessory molecule?

• CD2

• CD3

• CD4

• CD8

Patients who have received the following types of grafts are at risk for graft-versus-host disease (GVHD) except for recipients of

• bone marrow transplants.

• lung transplants.

• liver transplants.

• irradiated leukocytes.

Which of the following properties are not exhibited by HLA molecules?

• They belong to the immunoglobulin superfamily.

• They are heterodimeric.

• They are integral cell membrane glycoproteins.

• They are monomorphic.

Kidney allograft loss from intravascular thrombosis without cellular infiltration 5 days post-transplant may indicate which primary rejection mechanism?

• Hyperacute rejection

• Accelerated humoral rejection

• Acute humoral rejection

• Acute cellular rejection

Which reagents would be used in a direct (forward) donor–recipient crossmatch test?

• Donor serum and recipient lymphocytes + rabbit serum complement

• Recipient serum and donor lymphocytes + rabbit serum complement

• Donor stimulator cells + recipient responder cells + complete culture medium

• Recipient stimulator cells + donor responder cells + complete culture medium

The indirect allorecognition pathway involves which one of the following mechanisms?

• Processed peptides from polymorphic donor proteins restricted by recipient HLA class II molecules

• Processed peptides from polymorphic recipient proteins restricted by donor HLA class I molecules

• Intact polymorphic donor protein molecules recognized by recipient HLA class I molecules

• Intact polymorphic donor protein molecules recognized by recipient HLA class II molecules

Which immunosuppressive agent selectively inhibits IL-2 receptor-mediated activation of T cells and causes clearance of activated T cells from the circulation?

• Mycophenolate mofetil

• Cyclosporine mofetil

• Corticosteroids

• Daclizumab

Phenotyping for HLA class II antigens requires B lymphocytes because

• B lymphocytes express HLA class II antigens.

• B lymphocytes do not express HLA class I antigens.

• B lymphocytes are exquisitely sensitive to complement-mediated lysis.

• B lymphocytes represent the majority of lymphocytes in the peripheral blood.

A renal transplant candidate was crossmatched with a donor that was mismatched for only the HLA-B35 antigen. The candidate was known to have an anti body specific for HLA-B35. Which of the following combinations of T- and B-cell flow cytometric crossmatch results would be expected?

• T cell negative, B cell negative

• T cell positive, B cell positive

• T cell negative, B cell positive

• T cell positive, B cell negative