Normal vs. Sickle Cell Hemoglobin (Performance Task)

What type of mutation causes sickle cell anemia?

• Addition

• Deletion

• Substitution

• None

Which amino acid is replaced in sickle cell hemoglobin due to the mutation?

• Glutamic acid is replaced by valine

• Valine is replaced by glutamic acid

• Glycine is replaced by alanine

Mutation is any __________ in the sequence of DNA base pairs

Healthy red blood cells can move easily through __________ vessels

What is the normal codon in the DNA sequence for hemoglobin?

• GAG

• AGA

• CAG

• AAT

How do sickle-shaped red blood cells affect the body?

• They carry more oxygen than normal cells

• They move easily through blood vessels

• They can block blood flow and cause pain

• They break down food in the stomach

_______ _______ is the amino acid that helps hemoglobin maintain its proper shape.

If A pairs with C the gene will have mutation.

• True

• False