T Cell Biology and Function

The video tutorial covers T and B cell development, focusing on T cell maturation in the thymus, including negative and positive selection processes. It explains T cell activation, their role in immune response, and the differentiation into CD4+ and CD8+ T cells. The structure and signaling of the TCR complex are detailed, highlighting the importance of CD3 and ITAMs. The tutorial also discusses MHC classes, antigen presentation, and the concept of cross-presentation by APCs.

What is the process called when thymocytes with high affinity for self-peptide-MHC complexes undergo apoptosis?

• Cross-presentation

• Negative selection

• Positive selection

• Clonal expansion

Where do naïve mature T cells go after exiting the thymus?

• Bone marrow

• Peripheral lymphoid organs

• Bloodstream

• Liver

Which type of T cell is involved in the generation of antibody-producing B cells?

• Helper T cells

• Regulatory T cells

• Cytotoxic T cells

• CD8+ T cells

What are the two main types of T cells based on their surface markers?

• CD3 and CD4

• CD4 and CD8

• CD8 and CD3

• CD4 and CD2

What is the role of CD3 in the TCR complex?

• Antigen recognition

• Cell division

• Signal transmission

• Antibody production

Which chains in the CD3 complex contain ITAMs?

• CD3α/ε

• CD3ζ

• CD3γ/δ/ε

• CD3α/β

Which TCR genes form the majority of mature T cells?

• TCRγ and TCRδ

• TCRα and TCRβ

• TCRα and TCRγ

• TCRβ and TCRδ

What are the two classes of T cell ligands?

• HLA-A and HLA-B

• TCRα and TCRβ

• CD4 and CD8

• MHC class I and II

Which cells present antigen peptide-bound MHCII molecules?

• All nucleated cells

• Antigen-presenting cells

• Neurons

• Red blood cells

What is the process called when exogenous antigens are presented to the MHC I receptor?

• Clonal expansion

• Cross-presentation

• Negative selection

• Positive selection