Clinical Hematology Midterm Exam

A patient is suspected of having a factor deficiency. Considering the result of the mixing study, deficiency in what factor is the reason for the Px’s coagulation disorder PT: Normal aPTT: Prolonged aPTT + Fresh Plasma -> Corrected aPTT + Aged Plasma -> Corrected aPTT + Aged Serum -> Corrected aPTT + Adsorbed Plasma -> Not corrected

• Factor 10

• Factor 8

• Factor 2

• Factor 9

• Factor 5

Which of the following is the primary function of secondary hemostasis?

• Formation of a platelet plug

• Reinforcing the platelet plug with fibrin

• Degradation of fibrin

• Activation of platelets

What are zymogens?

• Inactive precursors of coagulation factors

• Active coagulation factors

• Platelet adhesion molecules

• Inhibitors of the coagulation cascade

Vitamin K deficiency can lead to a malfunction of which of the following factors? (Select all that apply)

• Factor II

• Factor V

• Factor VIII

• Factor IX

• Protein C

A patient suspected of having bleeding disorder was ordered by the physician to have mixing studies. Considering the result of the mixing study, deficiency in what factor is the reason for the Px’s coagulation disorder PT: Prolonged aPTT: Prolonged PT & aPTT + Fresh Plasma -> Corrected PT & aPTT + Aged Plasma -> Corrected PT & aPTT + Aged Serum -> Not Corrected PT & aPTT + Adsorbed Plasma -> Corrected

• Factor 10

• Factor 1

• Factor 2

• Factor 13

• No Factor deficiency

What pathway is affected in the case of the patient in the previous question? (Number 5)

• Intrinsic and Common

• Extrinsic and Common

• Intrinsic and Extrinsic

• Common

• No pathway affected

Aside from the tests conducted, what other procedures can help in identifying the deficiency of the patient in Number 5?

• Thrombin time

• Fibrinogen assay

• None

• 5M Urea

The intrinsic and extrinsic pathways of the coagulation cascade converge at which point?

• Activation of Factor XII

• Activation of Factor X

• Formation of a fibrin clot

• Exposure of tissue factor

Which of the following statements about cofactors in the coagulation cascade is TRUE?

• Cofactors can act as enzymes on their own.

• Cofactors enhance the activity of specific enzymes.

• All coagulation factors are also cofactors.

• Cofactors are consumed during the coagulation cascade.

The following statement is not TRUE about the Intrinsic tenase complex?

• COAT platelets serve as a platform for the intrinsic tenase and prothrombinase complex.

• It is composed of Factor IX, VIII, and XI

• The action of Intrinsic Tenase complex during in the in vivo coagulation leads to the generation of 95% or more total thrombin

• None of the above