Overview of Lymphoid Malignancies

What are the primary sites for leukemias?

• Bone marrow and peripheral blood

• Lymphoid tissues

• Bone marrow, lymphoid and non-lymphoid sites

• Peripheral blood

What is the malignant transformation of hematologic cells due to?

• Excessive accumulation

• Arrested maturation

• Retention of normal traits

• All of the above

What is the role of lymphocytes in immune responses?

• Proliferation

• Gene rearrangement

• Somatic hypermutation

• All of the above

What is a notable translocation in Burkitt Lymphoma?

• t(8;14)

• t(14;18)

• t(9;22)

• None of the above

What is the application of Gleevec (Imatinib)?

• Used in CML to inhibit abnormal tyrosine kinase activity

• Used in ALL treatment

• Used in MDS treatment

• None of the above

What is the primary focus of the WHO classification?

• Integrating cell lineage, morphology, immunologic markers, and genetic abnormalities

• Only cell morphology

• Only genetic abnormalities

• Only immunologic markers

What characterizes acute leukemias?

• Rapid onset and presence of immature blast cells

• Slow progression

• Presence of mature cells

• None of the above

What is the primary cell type involved in lymphocytic leukemias?

• B-lymphocytes

• T-lymphocytes

• Both A and B

• None of the above

What is the most common leukemia in children?

• Acute Lymphocytic Leukemia (ALL)

• Chronic Lymphocytic Leukemia (CLL)

• Chronic Myelogenous Leukemia (CML)

• Hairy Cell Leukemia (HCL)

What is the prognosis for children with Acute Lymphocytic Leukemia (ALL)?

• Remission rate: ~90%, Cure rate: ~80%

• Remission rate: ~50%, Cure rate: ~40%

• Remission rate: ~70%, Cure rate: ~60%

• Remission rate: ~30%, Cure rate: ~20%