Selvam Pt. 2

What crucial feature of a penicillin is involved in its mechanism of action?

• Thiazolidine Ring

• Carboxylic Acid

• Aromatic Ring

• Acyl Side Chain

• Beta Lactam Ring

Which of the following statements is true for the methoxy substituent at ortho position in aromatic ring?

• It is good for oral activity

• It is good for acid resistant

• The ortho-methoxy groups produced steric hindrance, increasing its affinity to B-lactamases

• The ortho-methoxy groups produced steric hindrance, decreasing its affinity to B-lactamases

• The ortho-methoxy groups produced steric hindrance, increasing its affinity to transpeptidase

Which of the following statements about Nafcillin is/are correct? SATA

• Nafcillin is acid sensitive penicillin

• Nafcillin is acid resistant penicillin

• Ethoxy group produced steric hindrance, decreasing its affinity to B-lactamases

• Nafcillin is a weak acid

• Nafcillin is a weak base

Penicillin Antibiotics contains:

• 5-membered lactam ring and 4 membered thiazolidine ring

• 4-membered lactam ring and 5 membered imidazole ring

• 4-membered lactam ring and 5 membered pyrazole ring

• 4-membered lactam ring and 6 membered thiazolidine ring

• 4-membered lactam ring and 5 membered thiazolidine ring

Tags

NGSS.HS-PS1-2

Beta lactam ring (Penicillin) biosynthesis:

• Condensation of Valine and Isoleucine

• Condensation of Valine and Leucine

• Condensation of Cysteine and Leucine

• Condensation of Cysteine and Valine

• Condensation of Cysteine and Glysine

Tags

NGSS.HS-LS1-1

NGSS.HS-LS1-6

Which of the following statements about procaine benzyl penicillin is/are correct?

• Procaine benzyl penicillin is water soluble and used for parenteral administration

• Procaine benzyl penicillin is more acid stable and is a acid resistant penicillin

• Procain benzyl penicillin is water insoluble and used for repository purposes

• Procaine benzyl penicillin is a beta lactase resistant penicillin

Which of the following statements about Methicillin is/are correct? SATA

• The ortho-methoxy groups produced steric hindrance, reducing its affinity to B-lactamases

• Methicillin is a weak acid

• It contains lactam and thiazolidine ring

• Methicillin is a B lactase resistant penicillin

• Methicillin is an acid sensitive penicillin

Which of the following statements about Ampicillin is/are correct? SATA

• Electron withdrawing character of the protonated primary amine group (NH3+), reducing participation in acid hydrolysis

• Ampicillin is amphoteric substance

• Ampicillin is a B lactamase sensitive penicillin

• Ampicillin is an acid resistant penicillin

Tags

NGSS.HS-PS1-2

Which of the following statements about Becampicillin is/are correct? SATA

• Becampicillin is amphoteric substance

• Becampicillin is a weak base

• Becampicillin is a pro-drug

• Becampicillin is a B lactamase sensitive penicillin

• Becampicillin is an acid resistant penicillin

The drug illustrated below is Ampicillin. How many chiral centers are present?

• 1

• 5

• 4

• 3

• 6