NRTIs and NNRTIs

match the mechanism of action

• NRTIs

• Competitive inhibition of reverse transcriptase leads to premature chain termination

• Integrase Inhibitors

• prevent integration of HIV ds-DNA to host cell DNA thus, interrupting the HIV replication cycle

• Protease Inhibitors

• responsible for maturation of new virus particles by cleaving  the Gag-Pol polyproteins

• NNRTIs

• Directly bind to HIV reverse transcriptase at a different site than NRTIs, resulting in blockade of enzyme activity

Which of the following medications is the prototype, a thymidine analog?

• tenofovir

• abacavir

• lamivudine

• emtricitabine

• zidovudine

Plasma level of active tenofovir 90% lower with which of the following?

• TAF

• TDF

Which of the following has more renal and bone toxicity?

• TAF

• TDF

Which of the following does not require dose adjustments in renally insufficient patients?

• TAF

• TDF

Which of the following meds is (are) approved for treatment of HBV infection?

• TAF

• TDF

• neither

• both

Which of the following meds is (are) a substrate for p-gp and thus affected by inducers and inhibitors?

• TAF

• TDF

• neither

• both

which of the following are known for reduced bone mineral density

• tenofovir

• zidovudine

• emtricitabine

• all agents

• abacavir

which of the following are known for nephrotoxicity

• tenofovir

• zidovudine

• emtricitabine

• all agents

• abacavir

which of the following are known for macrocytic anemia / neutropenia

• tenofovir

• zidovudine

• emtricitabine

• all agents

• abacavir