NRTIs and NNRTIs
University
•29 Qs
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NRTIs and NNRTIs
Quiz
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Other
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University
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Practice Problem
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Easy
Terry Robinson
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29 questions
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1.
MATCH QUESTION
1 min • 1 pt
match the mechanism of action
NNRTIs
prevent integration of HIV ds-DNA to host cell DNA thus, interrupting the HIV replication cycle
NRTIs
Directly bind to HIV reverse transcriptase at a different site than NRTIs, resulting in blockade of enzyme activity
Protease Inhibitors
Competitive inhibition of reverse transcriptase leads to premature chain termination
Integrase Inhibitors
responsible for maturation of new virus particles by cleaving the Gag-Pol polyproteins
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following medications is the prototype, a thymidine analog?
tenofovir
abacavir
lamivudine
emtricitabine
zidovudine
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Plasma level of active tenofovir 90% lower with which of the following?
TAF
TDF
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following has more renal and bone toxicity?
TAF
TDF
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following does not require dose adjustments in renally insufficient patients?
TAF
TDF
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following meds is (are) approved for treatment of HBV infection?
TAF
TDF
neither
both
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following meds is (are) a substrate for p-gp and thus affected by inducers and inhibitors?
TAF
TDF
neither
both
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