NRTIs and NNRTIs
Authored by Terry Robinson
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29 questions
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1.
MATCH QUESTION
1 min • 1 pt
match the mechanism of action
Integrase Inhibitors
Competitive inhibition of reverse transcriptase leads to premature chain termination
Protease Inhibitors
responsible for maturation of new virus particles by cleaving the Gag-Pol polyproteins
NNRTIs
prevent integration of HIV ds-DNA to host cell DNA thus, interrupting the HIV replication cycle
NRTIs
Directly bind to HIV reverse transcriptase at a different site than NRTIs, resulting in blockade of enzyme activity
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following medications is the prototype, a thymidine analog?
tenofovir
abacavir
lamivudine
emtricitabine
zidovudine
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Plasma level of active tenofovir 90% lower with which of the following?
TAF
TDF
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following has more renal and bone toxicity?
TAF
TDF
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following does not require dose adjustments in renally insufficient patients?
TAF
TDF
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following meds is (are) approved for treatment of HBV infection?
TAF
TDF
neither
both
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following meds is (are) a substrate for p-gp and thus affected by inducers and inhibitors?
TAF
TDF
neither
both
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