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NRTIs and NNRTIs

Authored by Terry Robinson

Other

University

Used 1+ times

NRTIs and NNRTIs
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29 questions

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1.

MATCH QUESTION

1 min • 1 pt

match the mechanism of action

Protease Inhibitors

responsible for maturation of new virus particles by cleaving  the Gag-Pol polyproteins

Integrase Inhibitors

Directly bind to HIV reverse transcriptase at a different site than NRTIs, resulting in blockade of enzyme activity

NNRTIs

prevent integration of HIV ds-DNA to host cell DNA thus, interrupting the HIV replication cycle

NRTIs

Competitive inhibition of reverse transcriptase leads to premature chain termination

2.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following medications is the prototype, a thymidine analog?

tenofovir

abacavir

lamivudine

emtricitabine

zidovudine

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Plasma level of active tenofovir 90% lower with which of the following?

TAF

TDF

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following has more renal and bone toxicity?

TAF

TDF

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following does not require dose adjustments in renally insufficient patients?

TAF

TDF

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following meds is (are) approved for treatment of HBV infection?

TAF

TDF

neither

both

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following meds is (are) a substrate for p-gp and thus affected by inducers and inhibitors?

TAF

TDF

neither

both

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