Which two medications are inactive against influenza B virus because the M2 protein is absent?

Peramivir and Baloxavir marboxil

Which of the following statements about Baloxavir marboxil is TRUE?

Chemoprophylaxis and treatment doses are the same

It is only available as an inhaled dosage form

It is recommended for use in pregnancy

Which of the following is NOT a notable characteristic of Remdesivir?

Should not be used in pregnant patients due to concerns for mutagenesis

Only available as an intravenous dosage form

Contains sulfobutyl ether beta-cyclodextrin sodium (SBECD)

Clinical significance in renal dysfunction is unclear

Why should Dexamethasone not be prescribed after hospital discharge for COVID-19 patients?

It is not beneficial in outpatients or those not requiring supplemental oxygen

It causes severe GI perforation

It is only available as an intravenous dosage form

It accumulates in renal dysfunction

What is a key consideration when prescribing Nirmatrelvir/ritonavir for COVID-19 treatment?

Drug-drug interactions must be evaluated before prescribing

It should be given intravenously

It is safe for use in pregnant patients

It should be avoided in patients with high bleeding risk

For which patients is Tocilizumab indicated in the treatment of COVID-19?

Patients receiving dexamethasone with rapidly increasing oxygen needs and systemic inflammation

Patients with mild symptoms and no oxygen needs

Patients with severe renal impairment only

Which of the following is a notable characteristic of Baricitinib in COVID-19 therapy?

Should not be used in patients with high bleeding risk or severe renal impairment

Only available as an intravenous dosage form

Causes neuropsychiatric symptoms

Should be used in all hospitalized patients regardless of oxygen needs

What is a notable characteristic of Valacyclovir compared to Acyclovir?

It is the L-valyl ester of acyclovir with enhanced bioavailability.

It is only available as a topical dosage form.

It is not virucidal and not a true antiviral.

It is only effective against non-replicating viruses.

Which of the following statements best describes the mechanism of action for Famciclovir?

It is an oral prodrug of penciclovir and only effective against replicating virus.

It is only available as a topical dosage form.

It is not virucidal and not a true antiviral.

It is the L-valyl ester of acyclovir.

What is the main adverse effect associated with Ganciclovir?

Myelosuppression (dose-dependent, reversible)

Which of the following is a notable characteristic of Valganciclovir?

It is a valine ester of ganciclovir and has higher bioavailability.

It is only available as a parenteral dosage form.

It is only effective against non-replicating virus.

It is a strong inhibitor of HSV polymerase.

Letermovir is primarily used for which purpose?

CMV prophylaxis following hematopoietic stem cell transplant for CMV-seropositive patients

Treatment of drug-resistant HSV infections

First-line therapy for tuberculosis

Which of the following statements best explains why Ganciclovir is considered a more effective inhibitor in vivo compared to acyclovir triphosphate?

It has a longer intracellular half-life and higher concentrations.

It is less toxic to the kidneys.

It is available as an oral dosage form.

It is effective against non-replicating viruses.

Which adverse effect is associated with Foscarnet?

Nephrotoxicity and symptomatic electrolyte disturbances

What is the recommended initial phase treatment regimen for active TB?

INH + Rifapentine weekly for 3 months

A patient with renal failure is diagnosed with TB. What is an important consideration in their treatment?

Adjust dosing and consider liver-sparing regimens

Why is Directly Observed Therapy (DOT) recommended in TB management?

It improves treatment outcomes by ensuring adherence

It reduces the cost of medication

It eliminates the need for laboratory tests

It shortens the duration of therapy

Which of the following best describes the pathophysiology of Herpes Simplex Virus (HSV)?

Latent in sensory ganglia; reactivates with stress/immunosuppression

Binds to ACE2 receptors in the lungs

Causes immune dysregulation in the liver

Viral Infections

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MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which antiviral medication is most commonly used for the prevention and treatment of influenza?

Zanamivir

Oseltamivir

Peramivir

Baloxavir marboxil

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which influenza medication requires renal dose adjustment?

Zanamivir and Baloxavir marboxil

Oseltamivir and Peramivir

Amantadine and Rimantadine

Zanamivir and Peramivir

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following is a notable adverse effect of Zanamivir?

Nausea and vomiting

Bronchospasm

Headache

Rash

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Why are Amantadine and Rimantadine currently not recommended for the treatment or chemoprophylaxis of influenza?

They are too expensive

They are only available as injections

There is widespread resistance to circulating strains of influenza A virus

They cause severe allergic reactions

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

A patient with COPD and asthma is being considered for influenza treatment. Which medication should be avoided?

Oseltamivir

Zanamivir

Peramivir

Baloxavir marboxil

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which medication is only available as an intravenous injection and is not used for chemoprophylaxis?

Oseltamivir

Zanamivir

Peramivir

Baloxavir marboxil

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Who or why should Baloxavir marboxil not be used in certain populations?

It causes bronchospasm

It is not effective against influenza B

It should not be used in immunocompromised hosts, hospitalized patients with influenza, pregnancy, or patients ≤ 5 years

It requires renal dose adjustment

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Viral Infections

Which antiviral medication is most commonly used for the prevention and treatment of influenza?

Which influenza medication requires renal dose adjustment?

Which of the following is a notable adverse effect of Zanamivir?

Why are Amantadine and Rimantadine currently not recommended for the treatment or chemoprophylaxis of influenza?

A patient with COPD and asthma is being considered for influenza treatment. Which medication should be avoided?

Which medication is only available as an intravenous injection and is not used for chemoprophylaxis?

Who or why should Baloxavir marboxil not be used in certain populations?

Which two medications are inactive against influenza B virus because the M2 protein is absent?

A patient is unable to take medications by mouth. Which influenza medication is most appropriate?

Which of the following statements about Baloxavir marboxil is TRUE?

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