Enzymes and Nucleotide Disorders Quiz

Which enzyme is deficient in Lesch-Nyhan syndrome?

• HGPRT

• PRPP synthetase

• ADA

• AMP deaminase

What is the end product of purine catabolism in humans?

• Urea

• Uric acid

• Allantoin

• Creatinine

De novo synthesis of pyrimidines begins with which of the following?

• Ribose-5-phosphate

• Carbamoyl phosphate

• PRPP

• Orotate

Allopurinol is used in the treatment of which condition?

• Orotic aciduria

• Gout

• SCID

• Phenylketonuria

Which of the following is NOT associated with primary gout?

• HGPRT deficiency

• PRPP synthetase overactivity

• Renal failure

• Increased purine synthesis

Which intermediate accumulates in Orotic aciduria?

• Uric acid

• Orotate

• Inosine

• Orotidine

Purine salvage pathway utilizes which of the following enzymes?

• Xanthine oxidase

• PRPP synthetase

• Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

• CPS II

The enzyme deficient in SCID is?

• Adenosine deaminase

• HGPRT

• PRPP synthetase

• Xanthine oxidase

What is the source of nitrogen in purine ring?

• Glycine

• Glutamine

• CO2

• Aspartate

Uric acid is mainly excreted by?

• Kidneys

• Liver

• Intestines

• Skin