Autoimmune Disease Quiz

Which complement proteins are commonly reduced during active SLE due to immune complex consumption?

• C1q and C1s

• C2 and C4

• C3 and C4

• C9 and C5

Which of the following autoantibodies is considered most specific for the diagnosis of SLE?

• Anti-dsDNA antibodies

• Anti-histone antibodies

• Anti-Sm (Smith) antibodies

• Anti-CCP antibodies

Which of the following organs is most commonly affected in SLE?

• Lungs

• Liver

• Kidneys (Lupus nephritis)

• Pancreas

Which of the following is the most characteristic skin manifestation of SLE?

• Butterfly (malar) rash

• Hyperpigmentation of the face

• Vitiligo

• Alopecia areata

The most specific laboratory marker for Rheumatoid Arthritis is:

• Anti-nuclear antibody (ANA)

• Anti-dsDNA antibodies

• Anti-cyclic citrullinated peptide (anti-CCP) antibodies

• Rheumatoid factor (RF)

Rheumatoid factor (RF) is an autoantibody directed against:

• Insulin

• Fc portion of IgG

• Myelin basic protein

• Thyroid-stimulating hormone receptor (TSHR)

Which type of hypersensitivity reaction is associated with Rheumatoid Arthritis?

• Type I (IgE-mediated)

• Type II (Antibody-mediated)

• Type III (Immune complex-mediated)

• Type IV (Cell-mediated)

Which type of antibodies are commonly found in Hashimoto's Thyroiditis?

• Anti-thyroid peroxidase (TPO) antibodies

• Anti-GAD antibodies

• Anti-dsDNA antibodies

• Anti-cardiolipin antibodies

Which of the following is a hallmark feature of Hashimoto's Thyroiditis?

• Hyperthyroidism

• Hypothyroidism

• Addison's disease

• Graves' disease

Which hormone is deficient in Type 1 Diabetes?

• Cortisol

• Insulin

• Glucagon

• Thyroxine