CL16 MCQ

Which cell type originates from the myeloid lineage?

• B cell

• T cell

• Natural Killer (NK) cell

• Neutrophil

• Plasma cell

What is the origin of all blood and immune cells?

• Mesenchymal stem cells

• Lymphoid stem cells

• Hematopoietic stem cells

• Myeloid progenitor cells

• Bone marrow stroma

Which immune cell is primarily responsible for killing virus-infected cells in an MHC class I-restricted manner?

• Helper T cell

• Cytotoxic T lymphocyte (CD8⁺)

• B cell

• NK cell

• Neutrophil

Which surface marker identifies helper T cells?

• CD8

• CD19

• CD56

• CD4

• CD14

The BTK gene mutation is associated with which immunodeficiency?

• X-linked agammaglobulinemia (XLA)

• SCID

• DiGeorge syndrome

• Chronic granulomatous disease

• Leukocyte adhesion deficiency

Which cell type has a respiratory burst used to kill pathogens?

• B cell

• Dendritic cell

• Neutrophil

• NK cell

• Plasma cell

Which primary immunodeficiency is characterized by thymic hypoplasia?

• XLA

• DiGeorge syndrome

• SCID

• CGD

• LAD

Which of the following best describes SCID?

• B cell defect only

• Combined T and B cell deficiency

• Neutrophil adhesion defect

• Deficiency in IgA production

• NK cell hyperactivity

Which of the following is most likely impaired in Chronic Granulomatous Disease (CGD)?

• B cell class switching

• CD4⁺ T cell development

• MHC class II presentation

• Phagocytic killing due to NADPH oxidase deficiency

• Plasma cell differentiation

Which immunodeficiency is characterized by delayed umbilical cord separation and poor wound healing?

• SCID

• Leukocyte Adhesion Deficiency (LAD)

• DiGeorge syndrome

• XLA

• CGD