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Tumor Immunology

Authored by Medmicro KKU

Health Sciences

University

Used 4+ times

Tumor Immunology
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5 questions

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1.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

Which of the following best describes a Tumor-Specific Antigen (TSA)?

An antigen expressed by both tumor and normal cells

A self-antigen overexpressed in cancer cells

An antigen arising from mutations unique to tumor cells

An antigen found only on embryonic tissues

A surface protein involved in angiogenesis

2.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

A key mechanism by which Natural Killer (NK) cells recognize and eliminate tumor cells is by detecting:

High expression of MHC class I molecules

Presence of neoantigens on tumor cells

Antigen presentation via dendritic cells

Loss or downregulation of MHC class I molecules

CD28 co-stimulation on T cells

3.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

Which of the following is considered a primary role of CD8+ cytotoxic T lymphocytes (CTLs) in anti-tumor immunity?

Promoting B cell differentiation

Direct killing of tumor cells via perforin and granzyme

Enhancing regulatory T cell function

Presenting antigen to naïve T cells

Inducing angiogenesis

4.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

Tumors have developed numerous strategies to evade immune surveillance. All of the following are recognized mechanisms of immune evasion EXCEPT:

Upregulation of MHC class I molecules

Downregulation of tumor antigens

Secretion of immunosuppressive cytokines, TGF-β

Recruitment of regulatory T cells (Tregs)

Expression of immune checkpoint molecules, PD-L1

5.

MULTIPLE CHOICE QUESTION

45 sec • 1 pt

Chimeric Antigen Receptor (CAR) T-cell therapy involves genetically modifying a patient's T cells. What component of the CAR construct is responsible for recognizing the antigen on the tumor cell?

CD3ζ signaling domain

Costimulatory domain (e.g., CD28 or 4-1BB)

Hinge region

Single-chain variable fragment

Transmembrane domain

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