pREFORMULATION

What is the primary goal of preformulation studies?

• Improve patient compliance

• Determine marketing strategy

• Understand the drug’s physicochemical properties

• Evaluate clinical trial design

Preformulation studies are conducted during which phase of drug development?

• Post-marketing

• Clinical trials

• Formulation development

• Preclinical development

Which of the following is a physical property studied during preformulation?

• Pharmacokinetics

• Particle size

• Toxicity

• Bioavailability

Crystalline forms of drugs are usually more stable than:

• Liquids

• Salts

• Amorphous forms

• Hydrates

Which property influences the dissolution rate and bioavailability of a drug?

• Melting point

• Particle size

• Odor

• Taste

The process of converting a drug into different crystal forms is referred to as:

• Partitioning

• Polymorphism

• Agglomeration

• Crystallization

Which method is most commonly used to determine particle size?

• Spectroscopy

• UV analysis

• Sieving method

• Gas chromatography

Amorphous forms of drugs typically have:

• Higher stability and lower solubility

• Lower solubility and higher melting point

• Higher solubility and lower stability

• No impact on solubility

What does the partition coefficient (log P) indicate?

• Drug flow property

• Drug's pKa value

• Distribution between lipid and aqueous phases

• Rate of metabolism

Which flow property is assessed to determine compressibility of powders?

• Viscosity

• Porosity

• Angle of repose

• Melting point