MCQ on Molecular Oncology-II_MCBIO24

Cancer is described as a genetic disease primarily at the level of which type of cells?

• Germline cells

• Somatic cells

• Stem cells

• Embryonic cells

Which of the following is NOT one of the two fundamental properties shared by cancer cells?

• Abnormal cell growth and division

• Metastatic spread

• Normal cellular differentiation

• Unregulated cell proliferation

The age-related incidence of cancer suggests that cancer develops from the accumulation of several:

• Viral infections

• Hormonal imbalances

• Mutagenic events in a single cell

• Inflammatory responses

In colorectal cancers, the formation of an adenoma or polyp often requires inactivating mutations in which gene?

• TP53

• Kras

• APC

• PI3K

Genomic instability in cancer cells can manifest as all of the following EXCEPT:

• Translocations

• Aneuploidy

• Perfectly maintained chromosome number

• DNA amplification

The Philadelphia chromosome is a hallmark of Chronic Myelogenous Leukemia (CML) and results from a translocation between which two chromosomes?

• Chromosome 11 and 22

• Chromosome 9 and 22

• Chromosome 13 and 17

• Chromosome X and Y

Which proto-oncogene, when altered by translocation, amplification, or point mutations, is associated with lymphomas, leukemias, and lung cancer?

• c-kit

• c-myc

• R A R alpha

• Cyclins

The Ras proto-oncogene encodes signal transduction molecules that are associated with the cell membrane and regulate:

• DNA repair

• Apoptosis

• Cell growth and division

• Immune response

The TP53 tumor-suppressor gene is the most frequently mutated gene in human cancers (50% of all cancers) and encodes a protein involved in:

• Lipid synthesis

• Transcription regulation

• Angiogenesis

• Cell adhesion

Metastasis-suppressor genes, when mutated or disrupted in metastatic tumors, affect the growth and development of which type of tumor?

• Primary tumor

• Benign tumors

• Metastatic tumors

• All types of tumors equally