Renal Cell Carcinoma (1)

What is the most common histologic subtype of RCC?

• Papillary

• Chromophobe

• Clear cell

• Collecting duct

Clear cell RCC originates from:

• Proximal tubule

• Loop of Henle

• Distal tubule

• Collecting duct

Most common site of metastasis in RCC:

• Bone

• Liver

• Lung

• Brain

Classic triad of RCC includes all except:

• Hematuria

• Flank pain

• Fever

• Palpable mass

Which cytogenetic abnormality is seen in clear cell RCC?

• Trisomy 7

• Chromosome 3p deletion

• Monosomy X

• Trisomy 17

Which RCC subtype is most likely to respond to immunotherapy?

• Papillary

• Chromophobe

• Collecting duct

• Clear cell

The T2b stage in TNM classification refers to tumor size:

• <4 cm

• 4-7 cm

• 7-10 cm

• >10 cm confined to kidney

Which of the following is not a standard imaging modality for staging RCC?

• CT abdomen

• MRI brain

• Chest X-ray

• CT chest

Paraneoplastic syndrome in RCC includes all except:

• Hypercalcemia

• Polycythemia

• Cushing syndrome

• Diabetes mellitus

Which gene is mutated in Von Hippel-Lindau syndrome associated with RCC?

• BRCA1

• FLCN

• VHL

• MET