Fibrinolysis

thrombin after it is formed during

the activation of the clotting factors.

measures the capability of the

patient’s blood to form thrombin.

Formation of thrombin – is the main objective of all

of these coagulation cascade as well as the activation

of the clotting factors is the formation of thrombin.

It begins a few hours after polymerization and cross

linking of fibrin.

convert

fibrinogen to fibrin.

Fibrinogen conversion to fibrin monomer

Action of thrombin

Activation of Factor ___

How does thrombin polymerize the fibrinogen molecule?

The fibrinogen will be acted upon by thrombin which releases

• fibrinopeptides.

• fibrin monomer

How does thrombin polymerize the fibrinogen molecule?

The fibrinopeptides a and b will be released exposing the specific center point of fibrin

molecule called

• fibrinopeptides.

• fibrin monomer

There will be cross linking of all of these fibrin

monomers

• polymerization

  of the fibrinogen.

• polymerization

  of the fibrin clot.