Fibrinolysis

thrombin after it is formed during

the activation of the clotting factors.

(a)  

measures the capability of the

patient’s blood to form thrombin.

(a)  

Formation of thrombin – is the main objective of all

of these coagulation cascade as well as the activation

of the clotting factors is the formation of thrombin.

(a)  

It begins a few hours after polymerization and cross

linking of fibrin.

(a)  

convert

fibrinogen to fibrin.

(a)  

Fibrinogen conversion to fibrin monomer

(a)  

Action of thrombin

Activation of Factor (a)  

How does thrombin polymerize the fibrinogen molecule?

The fibrinogen will be acted upon by thrombin which releases

• fibrinopeptides.

• fibrin monomer

How does thrombin polymerize the fibrinogen molecule?

The fibrinopeptides a and b will be released exposing the specific center point of fibrin

molecule called

• fibrinopeptides.

• fibrin monomer

There will be cross linking of all of these fibrin

monomers

• polymerization

  of the fibrinogen.

• polymerization

  of the fibrin clot.