PRCC_4MT-P1

Purine catabolism

• Creatine
• Blood Uric Acid
• Blood Urea Nitrogen
• Bilirubin

>95% exists as monosodium urates

• Creatine
• Blood Uric Acid
• Blood Urea Nitrogen
• Bilirubin

98 to 99% are reabsorbed in the proximal convoluted tubules (PCT)

• Creatine
• Blood Uric Acid
• Blood Urea Nitrogen
• Bilirubin

Blood Uric acid becomes _ in liver damage

• High
• Low

leukemia

• Increased nuclear metabolism and cell turn over
• Other causes of hyperuricemia
• Decreased uric acid (hypouricemia)

hemolytic disease

• Increased nuclear metabolism and cell turn over
• Other causes of hyperuricemia
• Decreased uric acid (hypouricemia)

lymphoma

• Increased nuclear metabolism and cell turn over
• Other causes of hyperuricemia
• Decreased uric acid (hypouricemia)

multiple myeloma

• Increased nuclear metabolism and cell turn over
• Other causes of hyperuricemia
• Decreased uric acid (hypouricemia)

polycythemia

• Increased nuclear metabolism and cell turn over
• Other causes of hyperuricemia
• Decreased uric acid (hypouricemia)

megaloblastic anemia

• Increased nuclear metabolism and cell turn over
• Other causes of hyperuricemia
• Decreased uric acid (hypouricemia)