Pharmacokinetics

What is bioavailability?

• The total amount of drug in the body

• The fraction of the originally given drug that reaches systemic circulation

• The rate of drug metabolism in the liver

• The effectiveness of a drug in treating a specific condition

Which route of administration typically has 100% bioavailability?

• Intravenous

• Oral

• Intramuscular

• Subcutaneous

Why is bioavailability particularly important in orally administered medications?

• It determines the drug's color

• It affects the drug's taste

• The digestive process can impact the amount of drug reaching circulation

• It influences the drug packaging

Why is intravenous administration considered the best for high bioavailability?

• It's the easiest method

• It allows for gradual drug release

• All the drug goes straight into circulation

• It has fewer side effects

In orally administered medications, what can reduce bioavailability?

• Drug color

• Stomach acidity and digestive enzymes

• Drug taste

• Drug packaging

What is drug distribution in the body primarily influenced by?

• Drug taste

• Drug color

• Blood flow

• Drug odor

How do physicochemical properties influence drug distribution?

• Drug temperature

• Drug size, shape, and polarity

• Drug sound

• Drug brightness

What role does protein binding play in drug distribution?

• Facilitates drug distribution to tissues

• Reduces drug effectiveness

• Enhances drug taste

• Causes drug color change

What happens to the pharmacologically active fraction of a drug that binds to proteins in the blood?

• It becomes inactive

• It is excreted unchanged

• It is distributed to tissues

• It turns into a different drug

What does tissue permeability refer to in pharmacology?

• The ability of a drug to pass through cell membranes and barriers

• The ability of a drug to dissolve in water

• The chemical stability of a drug

• None of the above