Pharmacology Multiple Choice Questions

Pharmacogenomics is the study of:

• How genes affect the ability to respond to medications

• How medications move through the body

• How medications are used in a population

• How medications are distributed throughout the body

Pharmacokinetics is the study of:

• How a population metabolizes a medication

• What type of response a person will have to a medication

• How a medication is metabolized in a person

• How a person’s genes may alter a medication’s response

Which of the following best describes the term half-life?

• The amount of time it takes to clear a medication from the body

• The time it takes for a medication to achieve its peak effect

• The amount of time it takes for a medication to achieve its peak concentration

• The time it takes for a medication to decrease its concentration by 50%

Which of the following best describes minimum inhibitory concentration?

• Lowest concentration of an antibiotic necessary to inhibit bacterial growth

• Lowest concentration of a medication needed to achieve a response

• Lowest concentration of a medication necessary to inhibit undesirable side effects

• Lowest concentration of a medication needed to inhibit first-pass metabolism

Which of the following best describes the concept of the area under the curve (AUC)? It is a measure of:

• How a medication is metabolized after oral ingestion

• How medications are cleared from the body

• The effect of a medication on the body

• The bioavailability of a medication

Which of the following best describes the concept of bioavailability?

• Tolerability of a medication to be given orally

• Way a medication is absorbed and used by the body

• Amount of drug necessary to achieve peak effect

• Way genes affect the metabolism of a medication

Which of the following is/are the main organ/s of biotransformation?

• Kidneys

• Small intestines

• Large intestines

• Liver

Which of the following best describes the concept of first-pass metabolism?

• Medications administered orally must first be metabolized in the liver.

• Medications given sublingually must first be metabolized in the small intestines.

• Medications given intramuscularly must first pass from intestine to liver before reaching general circulation.

• Medications given intravenously must first be metabolized in the liver.

Which of the following best describes a CYP450 inducer?

• An additive to a medication to increase its absorption

• A medication that increases the clearance of other medications

• A medication that decreases the clearance of other medications

• An additive to a medication to decrease the firstpass effect

Which of the following best describes a CYP450 inhibitor?

• A medication that decreases the clearance of other medications

• A medication that prevents the degradation of its chemical compound

• An additive to a medication to decrease the firstpass effect