MEDL 201 Chapter 7 Complement System

The pathways of the complement system are:

• Classical, alternative, and lectin pathways

• Intrinsic, extrinsic, and common pathways

• Direct, indirect, and adaptive pathways

• Primary, secondary, and tertiary pathways

System controls in the context of the complement system are:

• mechanisms that regulate the activation and function of the complement system

• proteins that directly destroy pathogens without regulation

• enzymes that only activate the complement cascade

• cells that produce antibodies against complement proteins

Complement receptors are proteins that play which of the following biological roles?

• They bind complement proteins and mediate immune responses such as phagocytosis and inflammation.

• They synthesize antibodies to fight infections.

• They transport oxygen in the blood.

• They break down pathogens directly without immune cell involvement.

The biological manifestations of complement activation include:

• Opsonization, chemotaxis, cell lysis, and inflammation

• DNA replication and repair

• Hormone secretion and regulation

• Neurotransmitter release and synaptic transmission

Complement therapeutics are:

• drugs that target the complement system to treat diseases

• vitamins that enhance immune function

• antibiotics used to kill bacteria

• supplements for improving digestion

Complement abnormalities are detected in the laboratory by which of the following methods?

• Measurement of complement levels and functional assays

• Urine analysis

• Electrocardiogram (ECG)

• Liver function tests

Complement is a series of more than ___ soluble and cell-bound proteins that interact to enhance host defense mechanisms against foreign cells.

• 50

• 10

• 20

• 5

Where are most plasma complement proteins synthesized?

• In the liver

• In the spleen

• In the bone marrow

• In the pancreas

Which of the following is NOT an exception to the synthesis of plasma complement proteins in the liver?

• C1 components (produced by intestinal epithelial cells)

• Factor D (made in adipose tissue)

• Albumin (produced by the liver)

• None of the above

True or False: All plasma complement proteins are synthesized in the liver.

• True

• False