NSAIDs/muscle relaxants/opioidsMultiple Choice Questions

What is the primary mechanism of action of NSAIDs?

• Inhibition of leukotriene synthesis

• Inhibition of cyclooxygenase (COX) enzymes

• Activation of histamine receptors

• Stimulation of prostaglandin production

Which of the following is NOT a therapeutic effect of NSAIDs?

• Antipyretic

• Anticoagulant

• Anti-inflammatory

• Sedative

Aspirin is classified as:

• A selective COX-2 inhibitor

• A nonselective COX inhibitor

• A leukotriene inhibitor

• A proton pump inhibitor

Acetaminophen differs from NSAIDs because it:

• Has anti-inflammatory effects

• Inhibits thromboxane synthesis

• Lacks significant anti-inflammatory and anticoagulant effects

• Is a selective COX-2 inhibitor

COX-2 selective inhibitors are associated with an increased risk of:

• Gastric ulcers

• Liver toxicity

• Cardiovascular events (e.g., heart attack, stroke)

• Renal failure

Which of the following is a COX-2 selective inhibitor?

• Ibuprofen

• Aspirin

• Celebrex

• Naproxen

Acetaminophen toxicity primarily affects which organ?

• Kidneys

• Liver

• Heart

• Lungs

What is the primary difference between spasticity and muscle spasms?

• Spasticity is caused by CNS lesions; spasms are caused by musculoskeletal injuries.

• Spasticity is voluntary; spasms are involuntary.

• Spasticity is temporary; spasms are permanent.

• Spasticity is painless; spasms are painful.

Which drug is a benzodiazepine used for both muscle spasms and spasticity?

• Baclofen

• Diazepam

• Dantrolene

• Tizanidine

Baclofen primarily acts by:

• Blocking calcium release in muscle cells.

• Enhancing GABAB receptor activity in the spinal cord.

• Inhibiting acetylcholine release at the neuromuscular junction.

• blocking calcium release in presynaptic neurons