Rheumatoid Arthritis (RA) and OA Questions

What is the primary pathological feature of rheumatoid arthritis (RA)?

• Degeneration of articular cartilage

• Synovitis and destruction of articular tissue

• Formation of osteophytes

• Accumulation of uric acid crystals

Which drug category is now considered the first line of defense in treating RA due to its disease-modifying properties?

• NSAIDs

• Glucocorticoids

• DMARDs

• Acetaminophen

What is the mechanism of action of NSAIDs in RA?

• Inhibiting COX enzymes to reduce prostaglandin synthesis

• Blocking TNF-alpha

• Suppressing T-cell activation

• Chelating heavy metals

Which of the following is a common adverse effect of long-term NSAID use?

• Retinal toxicity

• Gastric ulceration and hemorrhage

• Muscle wasting

• Increased risk of infection

Why are COX-2 selective NSAIDs sometimes preferred over traditional NSAIDs?

• They are more effective at reducing inflammation.

• They spare COX-1, reducing GI toxicity.

• They have no cardiovascular risks.

• They are cheaper.

Which DMARD is commonly used as the cornerstone of RA treatment due to its rapid onset and efficacy?

• Penicillamine

• Methotrexate

• Gold compounds

• Hydroxychloroquine

What is the primary mechanism of methotrexate in RA?

• Inhibiting folic acid synthesis

• Blocking interleukin-1 receptors

• Chelating copper

• Stimulating prostaglandin production

Which of the following is a biological DMARD that targets TNF-alpha?

• Methotrexate

• Etanercept

• Hydroxychloroquine

• Leflunomide

What is a major risk associated with TNF-alpha inhibitors?

• Improved immune function

• Increased risk of infection

Which DMARD specifically targets T-cell activation?

• Abatacept

• Rituximab

• Anakinra

• Tocilizumab