Hypothalamic & Pituitary Medications and Endocrine Disorders

Which drug is a recombinant form of human IGF-1 used for children with severe IGF-1 deficiency unresponsive to growth hormone?

• Octreotide

• Mecasermin

• Pegvisomant

• Pasireotide

Which agent acts as a GH receptor antagonist used for acromegaly but may increase GH levels?

• Somatostatin

• Octreotide

• Pegvisomant

• Mecasermin

Which somatostatin analog has a higher affinity for receptor subtype 5 and provides greater control of acromegaly?

• Octreotide

• Pasireotide

• Lanreotide

• Somatostatin

Menotropins (hMG) are purified from:

• Placental tissue

• Urine of postmenopausal women

• Pituitary extract

• Human serum

Continuous administration of a GnRH analog results in:

• Increased LH and FSH secretion

• Decreased LH and FSH secretion

• Increased testosterone production

• Increased ovulation frequency

Which GnRH analog is commonly administered intranasally for controlled ovarian stimulation?

• Leuprolide

• Nafarelin

• Triptorelin

• Histrelin

Which GnRH receptor antagonist is approved for men with advanced prostate cancer?

• Ganirelix

• Cetrorelix

• Degarelix

• Gonadorelin

Dopamine normally inhibits prolactin secretion by:

• D1 receptor activation

• D2 receptor activation

• Beta-adrenergic receptor blockade

• Increased cAMP production

Answer explanation

This is another G-protein coupled receptor that decreases cAMP and is not under feedback control of peripheral tissues

Which drug is used to treat hyperprolactinemia?

• Bromocriptine

• Risperidone

• Metoclopramide

• TRH

Hyperprolactinemia can be induced by:

• Dopamine agonists

• Dopamine antagonists

• Glucocorticoids

• Thyroxine