Exam 2 PBSI 235 Review

Which of the following enzyme(s) is/are responsible for the synthesis of acetylcholine?

• • a) Tyrosine hydroxylase

• b) Tryptophan hydroxylase

• c) DOPA decarboxylase

• d) Choline acetyltransferase

• e) Monoamine oxidase A

The breakdown of acetylcholine in the synaptic cleft is primarily mediated by:

• • a) Monoamine oxidase B

• b) Acetylcholinesterase

• c) Catechol-O-methyltransferase

• d) Choline acetyltransferase

Select all ionotropic receptors for acetylcholine:

• a) Nicotinic

• b) Muscarinic

• c) NMDA

• d) GABA-A

Select all metabotropic receptors for acetylcholine:

• a) Nicotinic

• b) Muscarinic

• c) AMPA

• d) GABA-B

Which of the following statements is/are true?

• a) Curare blocks nicotinic acetylcholine receptors.

• b) Atropine blocks nicotinic acetylcholine receptors.

• c) Acetylcholine at the neuromuscular junction produces IPSPs.

• d) The primary mechanism of ACh signal termination is enzymatic degradation.

Myasthenia gravis is treated pharmacologically by drugs that:

• a) Inhibit acetylcholinesterase

• b) Stimulate acetylcholinesterase

• c) Reduce acetylcholine release

• • d) Block nicotinic receptors

Match the dopaminergic pathway with its primary function:

• Mesocortical system → ______

• a) Cognition

• b) Reward and pleasure

• c) Movement

• d) Prolactin secretion

Match the dopaminergic pathway with its primary function:

• Mesolimbic system → ______

• a) Cognition

• b) Reward and pleasure

• c) Movement

• d) Prolactin secretion

Match the dopaminergic pathway with its primary function:

• Nigrostriatal system → ______

• a) Cognition

• b) Reward and pleasure

• c) Movement

• d) Prolactin secretion

Match the dopaminergic pathway with its primary function:

• Tuberoinfundibular pathway → ______

• a) Cognition

• b) Reward and pleasure

• c) Movement

• d) Prolactin secretion