MHC and Antigen Presentation Quiz

This MHC is low in hepatocytes.

• MHC class I

• MHC class II

• MHC class III

The endogenous antigen processing pathway mainly involves which type of MHC molecule?

• MHC Class I

• MHC Class II

• MHC Class III

• MHC Class IV

HLA that protects fetus during pregnancy.

• HLA-A

• HLA-E

• HLA-F

• HLA-G

Which organelle is most directly involved in the degradation of endocytosed material?

• Golgi apparatus

• Proteasome

• Endoplasmic reticulum

• Lysosome

Transport of antigenic peptides from the cytosol into the ER in the endogenous pathway is mediated by:

• Clathrin

• TAP proteins

• SNAREs

• Dynamin

This is the goal of endogenous pathway.

• cell lysis

• present of peptides to CD4

• binding to MHC class II

• all are associated to endogenous pathway

Which among these does not relate with MHC class I molecule?

• Has four domains

• Involves stabilization using B2-microglobulin

• Has only one heavy chain

• Shorter peptides can bind at the cleft

What is the average length of amino acids a MHC class I can bind?

• 5-10 a.a.

• 8-11 a.a.

• 8-16 a.a.

• 10-30 a.a.

The genes encoding MHC molecules are located on which chromosome in humans?

• Chromosome 1

• Chromosome 3

• Chromosome 6

• Chromosome 12

In transplantation, MHC mismatch can lead to:

• Tolerance induction

• Autoimmunity

• Graft rejection

• Apoptosis of donor cells