Practice Questions 1-3: Histology & Microbiology

Cerebellar cortex micrograph shows a distinct single row of large neurons separating the outer pale layer from the inner densely packed layer. In which cerebellar layer are these cells located?

• Molecular layer

• Granular layer

• Ganglionar layer

At the bedside, which immediate tests are used for the examination of Liquor Cerebro Spinalis (LCS)?

• Only Nonne test

• Nonne and Pandi Test

• Microscopic Examination

• Culture Resistance test

• Only Pandi test

A neonate with ventriculitis has CSF cultured (A) and shows Gram-positive cocci in clusters on Gram stain (B). Which culture medium is most appropriate for this organism?

• MSA

• ChromAgar

• Blood agar

• TSIA

• LJ media

A 37-year-old woman with HIV presents with fever, seizures, and vomiting for 5 days. Brain CT shows an irregular ring-enhancing lesion with edema and mass effect. Biopsy of the brain lesion reveals organisms indicated by the arrow in the provided micrograph. What diagnostic feature is shown?

• Toxoplasma trophozoites

• Monocytoid cell

• Epitheloid histiocytes

• Plasma cell

• Tuberculoma

A bacterial staining result shows pink bacilli against a blue cellular background, as indicated by arrows in the smear image. What is the name of this staining method?

• ZN

• India Ink

• Albert

• Gram

• Gins Bury

In a histologic section of the cerebellar cortex, the arrow points to the large flask-shaped neurons located between the molecular and granular layers. What is the name of this cell?

• Satellite cell

• Purkinje cell

• Ganglion cell

Histology image shows a nerve fascicle surrounded by a distinct sheath indicated by an arrow. What is the name of this tissue layer?

• Endoneurium

• Epineurium

• Perineurium

A 60-year-old man presents with sudden onset of left leg paralysis and minimal movement in the left arm. He is diagnosed with ischemic stroke. On the cerebral angiogram provided, which numbered vessel is the most likely site of occlusion causing these findings?

• 4

• 3

• 1

• 2

• 5

A 35-year-old man has a 1-month history of headache and vomiting with no neurocognitive deficit. CT shows a brain lesion; biopsy image is provided. Based on the histology shown, what is the most likely diagnosis?

• Glioblastoma multiforme

• Gliosarcoma

• Astrocytoma

• Cerebral metastasis

• Ependymoma

A 28-year-old woman presents with persistent headache, fatigue, and problems with movement and coordination. Brain MRI shows a suspicious lesion, and biopsy reveals a diffusely infiltrative glial neoplasm composed of mildly atypical astrocytic cells with increased cellularity and fibrillary background. What is the most likely diagnosis?

• Glioblastoma

• Oligodendroglioma

• Diffuse astrocytoma

• Encephalitis

• Multiple sclerosis