Exam5 Chemistry pt 1

name this drug that comes as a racemic mixture( R & S)

• dobutamine

• dopamine

• digoxin

MOA: this drug activates cardiac B1 receptors leading to an increase in cAMP which leads to L-type voltage sensitive Ca channels to open. when the muscle contraction occurs the HR( chronotropic effect), aht force of contraction ( inotropic effect) are increased leading to an increase in cardiac output and O2 consumption

• dobutamine

• dopamine

• digoxin

name this drug

• dobutamine

• dopamine

• digoxin

• milrinone

Dobutamine: The S-isomer has .......activity

• 
• 

this drug is a ....used only short term as an adjunct in CHF

• glycoside

• PDE3 inhibitor

• dopamine analogue

the mOA of this drugs involves inhibiting the hydrolysis of cAMP by

• digoxin

• milrinone

• dobutamine

this drug is a ....used only short term as an adjunct in CHF

• glycoside

• PDE3 inhibitor

• dopamine analogue

Dobutamine: The R-isomer has .......activity

• 
• 

the steriochemistory at the chiral center of dobutamine affects activity but not

• selectivity

• receptor affinity

what is negative of dobutamine

• rapidly metabolized by COMT and has a short duration of action

• not orally active

• all the above