Cortisol Deficiency

Cortisol normally maintains blood glucose levels by stimulating gluconeogenesis. What happens if cortisol is chronically low?

• Hypoglycemia

• Hyperglycemia

• No effect on glucose metabolism

Under normal conditions, cortisol keeps the immune system 'under control'. What happens with chronic reduction of cortisol?

• Immunosuppression and poor healing

• Autoimmune reactions

• Increased immunity

In the cardiovascular system, cortisol normally maintains vascular tone and supports the action of catecholamines. What cardiovascular change would you expect with low levels of cortisol?

• Bradycardia and increased cardiac output

• Hypertension and tachycardia

• Hypotension and Bradycardia

Normal function of cortisol: it maintains collagen and bone metabolism. What effect do low levels of cortisol have on these tissues?

• Improved Collagen Synthesis, and delayed healing (But not really a big deal!)

• Excessive bone resorption and thin skin

• Promotes collagen synthesis and bone strength

In the CNS, cortisol normally regulates mood, alertness, and circadian rhythm. What behavioral change could occur in animals with chronic low cortisol?

• Calmness and improved sleep quality

• Letargy, apathy, depression

• Increased irritability, anxiety, and restlessness

Cortisol maintains a balanced distribution of fat and muscle. What change in body composition is expected in an animal with reduced cortisol?

• Truncal obesity and muscle wasting

• Lean body condition with no weight changes

• Weight loss and poor body condition

In the kidney, cortisol maintains a regulated GFR (glomerular filtration rate), inhibits ADH, and maintains Na+/K+ balance. What renal effect best reflects low cortisol levels?

• Normal GFR, with water retention

• Decreased GFR and concentrated urine

• Polyuria and polydipsia due to decreased sensitivity to ADH