QUIZ FMS 1 WEEK 1-4

Misfolding of polypeptides is a serious problem in cells. Which of the following diseases is NOT associated with an accumulation of misfolded proteins?

• Graves’ disease

• Creutzfeldt-Jakob Disease

• Kuru

• Alzheimer Disease

• Parkinson

The following pedigree is characteristic for a disease which is inherited in ________ manner.

• X-linked recessive

• X-linked dominant

• Autosomal dominant

• Mitochondrial

• Autosomal Recessive

Interaction between an enhancer sequence and an activator in the regulation of gene expression is an example of:

• DNA-DNA interaction

• RNA-protein interaction

• Protein-protein interaction

• DNA-RNA interaction

• DNA-protein interaction

Chaperone molecules bind to proteins targeted into organelles to …

• Modify the proteins

• Cleave signal sequences

• Direct the transport

• Prevent premature folding

• Destroy protein folding

In eukaryotic cells, transcription cannot begin until …

• The 5’ caps are removed from the mRNA

• The two DNA strands have completely separated and exposed the promoter

• DNA nucleases have isolated the transcription unit

• Several transcription factors have bound to the promoter

• The DNA introns are removed from the template

The following pedigree is an example of ______ inheritance.

• X-linked recessive

• Autosomal dominant

• Mitochondrial

• X-linked dominant

• Autosomal recessive

Carriers of balanced Robertsonian translocation may have offspring with __________.

• Normal chromosomes

• Balanced Robertsonian translocation

• Loss of a chromosome

• A and B

• A, B and C

Misfolded proteins in the ER are transported to _____ covalently linked to _____ and degraded in the _____

• Cytosol, Poly-Ubiquitin, Proteasome

• Cytosol, Poly-Lysin, Proteasome

• Golgi apparatus, Poly-Lysin, Lysosome

• Cytosol, Poly-Ubiquitin, Autophagy

• Golgi apparatus, Poly-Ubiquitin, Lysosome

Which of the following is/are true regarding a synonymous single nucleotide polymorphism (SNP)?

• A change in a nucleotide in the DNA sequence results in coding for the same amino acid

• Will always result in a change in function of the protein

• Is a product of genetic variation in the non–coding region

• A change in a nucleotide in the DNA sequence results in coding of a different amino acid

• Is a product of genetic variation in the intron region

Which one of the following statements describes essential amino acids?

• They are stored in adequate amounts so are not needed in the diet

• They are ingested but not used in protein synthesis

• They are less important in cells than non-essential amino acids

• They must be included in our diet because humans cannot synthesize them

• They can be synthesized from non-essential amino acids