Elimination Reactions and Alkene Stability

What is the main difference between a Zaitsev product and a Hofmann product in an elimination reaction?

• Zaitsev products are always larger molecules.

• Hofmann products are always smaller molecules.

• Zaitsev products are more substituted (have more groups attached to the double bond carbons) than Hofmann products.

• Hofmann products are more substituted (have more groups attached to the double bond carbons) than Zaitsev products.

Which type of alkene is generally the most stable?

• Unsubstituted alkene

• Mono-substituted alkene

• Di-substituted alkene

• Tetra-substituted alkene

The Zaitsev product is considered more stable and is therefore favored under conditions that allow the reaction to reach its most stable state. What is this type of product called?

• Kinetic product

• Unstable product

• Thermodynamically favored product

• Sterically hindered product

If a base is very large and bulky, which type of elimination product is it more likely to form?

• Zaitsev product

• Hofmann product

• Both Zaitsev and Hofmann products equally

• No product will be formed

Which type of alkene product is generally more stable and has more groups attached to its double bond?

• Hoffman product

• Zaitsev product

• Markovnikov product

• Anti-Markovnikov product

Which type of alkene product is formed faster when a large, bulky base is used in an elimination reaction?

• Zaitsev product

• Markovnikov product

• Hoffman product

• Anti-Markovnikov product

For an E2 elimination reaction to occur in a cyclic molecule, what must be the relationship between the hydrogen atom being removed and the leaving group?

• They must be on the same side of the molecule.

• They must be directly opposite each other.

• They must be in equatorial positions.

• They must be in syn-periplanar positions.

In the second example shown, why is only one elimination product formed, even though there appear to be multiple hydrogen atoms that could be removed?

• The base is too small to reach other hydrogen atoms.

• Only hydrogen atoms that are anti to the leaving group can be removed.

• The reaction only favors the most stable product.

• The molecule can only form one type of double bond.