Peptic Ulcer Disease Quiz

Drugs used in peptic ulcer disease include all EXCEPT

• Proton pump inhibitors

• H2 receptor blockers

• Antacids

• Beta blockers

Proton pump inhibitors act by

• Blocking histamine receptors

• Inhibiting H+/K+ ATPase in parietal cells

• Blocking muscarinic receptors

• Neutralizing gastric acid directly

Example of proton pump inhibitor is

• Omeprazole

• Ranitidine

• Sucralfate

• Magnesium hydroxide

Main therapeutic use of PPIs is

• Treatment of peptic ulcer and GERD

• Asthma

• Hypertension

• Diabetes

Common adverse effect of PPIs is

• Headache and diarrhea

• Severe sedation

• Bradycardia

• Polycythemia

Long-term use of PPIs may cause

• Vitamin B12 deficiency

• Hyperglycemia

• Polycythemia

• Hypokalemia

Ranitidine belongs to class

• H1 blocker

• H2 receptor blocker

• Proton pump inhibitor

• Antacid

Advantage of ranitidine over cimetidine is

• More drug interactions

• Less drug interactions and endocrine effects

• More antiandrogen effects

• Shorter duration

Cimetidine adverse effect includes

• Gynecomastia and impotence

• Hypoglycemia

• Renal failure

• Hyperthyroidism

Sucralfate acts by

• Neutralizing acid

• Forming protective barrier over ulcer base

• Inhibiting proton pump

• Blocking H2 receptors