Cystic Fibrosis: Key Concepts and Pathophysiology

Cystic fibrosis (CF) is a genetic disorder caused by a recessive gene affecting ion transport, leading to thick mucus in organs like the lungs and pancreas. It is most common in Caucasians. The CF gene's defect impacts sodium and chloride transport, causing widespread symptoms. Treatments focus on managing symptoms, such as using vests to clear lung mucus. The disease's name reflects scarring in the pancreas, but CF affects multiple body systems.

What is the inheritance pattern of Cystic Fibrosis?

• Mitochondrial

• X-linked

• Recessive

• Dominant

Tags

NGSS.HS-LS3-1

NGSS.HS-LS3-2

How many copies of the defective gene are required for a person to have Cystic Fibrosis?

• None

• One

• Two

• Three

Which population has the highest frequency of the Cystic Fibrosis gene?

• African

• Hispanic

• Asian

• Caucasian

Tags

NGSS.HS-LS3-3

What does the defective CF gene affect?

• Bone density

• Blood cell production

• Muscle growth

• Ion transport

Tags

NGSS.HS-LS3-2

Which organ is most affected by Cystic Fibrosis?

• Kidneys

• Liver

• Lungs

• Heart

What is a common treatment for clearing mucus in CF patients?

• Antibiotics

• Vest therapy

• Exercise

• Dietary supplements

What role does the pancreas play in Cystic Fibrosis?

• Both A and C

• Produces insulin

• Filters blood

• Produces digestive enzymes

Why do CF patients often have malnutrition?

• Excessive exercise

• Lack of sunlight

• Inability to absorb nutrients

• Lack of appetite

What is a unique symptom of Cystic Fibrosis related to sweat?

• Lack of sweating

• Colored sweat

• Salty taste

• Excessive sweating

Why is Cystic Fibrosis named so?

• Due to the cysts in the pancreas

• Because of lung infections

• Due to the fibrosis in the liver

• After the doctor who discovered it