Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)

The video tutorial covers cardiovascular pharmacology, focusing on ACE inhibitors and their role in managing high blood pressure. It explains the renin-angiotensin-aldosterone system (RAAS) and how ACE inhibitors disrupt this system to lower blood pressure. The tutorial also discusses the effects of angiotensin II on blood pressure and hormone release, highlighting the importance of aldosterone and ADH in blood pressure regulation.

Which suffix is commonly found in the names of ACE inhibitors?

• -pril

• -dipine

• -olol

• -sartan

What is the primary function of the renin-angiotensin-aldosterone system?

• Regulate heart rate

• Regulate blood pressure

• Regulate body temperature

• Regulate blood sugar levels

What enzyme converts angiotensin I to angiotensin II?

• Renin

• ADH

• Aldosterone

• ACE

Which receptor does angiotensin II primarily activate to increase blood pressure?

• AT1R

• Beta-1

• Alpha-1

• M3

What effect does the activation of AT1R have on vascular smooth muscle cells?

• Increases contractility

• Increases sodium excretion

• Decreases contractility

• Decreases calcium release

How do ACE inhibitors lower blood pressure?

• By increasing renin release

• By blocking angiotensin II receptors

• By inhibiting the conversion of angiotensin I to angiotensin II

• By increasing aldosterone secretion

What is the result of decreased angiotensin II levels due to ACE inhibitors?

• Increased ADH release

• Decreased aldosterone secretion

• Increased contractility of smooth muscle

• Increased blood pressure