Autoimmune Diseases Are Sexist. Here’s Why

The video explores the gender disparity in autoimmune diseases, focusing on the role of X chromosomes. It discusses how X inactivation might contribute to autoimmune disorders and highlights recent research suggesting that the process itself could be a factor. The video also touches on the potential for early detection through screening for antibodies related to X inactivation.

What is the primary focus of the initial discussion on autoimmune diseases?

• The historical neglect of women's healthcare needs

• The genetic basis of autoimmune diseases

• The role of diet in autoimmune diseases

• The impact of environmental factors

What genetic condition is characterized by having an extra X chromosome?

• Trisomy X

• Turner syndrome

• Klinefelter syndrome

• Down syndrome

What is the process called that prevents extra genes on the X chromosome from being expressed?

• Gene duplication

• Gene mutation

• Chromosome silencing

• X inactivation

Which molecule is involved in the X inactivation process?

• Histone

• DNA helicase

• EXIST

• RNA polymerase

What did the 2020 study on female mice with lupus-like disease find?

• No change in gene expression

• Excessive expression of X-linked genes

• Reduced expression of X chromosome genes

• Increased expression of Y chromosome genes

What was a key finding of the 2024 study involving male mice?

• Male mice naturally develop lupus

• EXIST expression in male mice worsens lupus symptoms

• EXIST has no effect on lupus symptoms

• Male mice are immune to lupus

What potential diagnostic tool is suggested by the recent research findings?

• Microbial gut analysis

• Genetic testing for X chromosome mutations

• Dietary analysis

• Screening for antibodies to EXIST