Serotonin Biosynthesis from Tryptophan

The video tutorial explains the biosynthesis of serotonin from L-Tryptophan, highlighting the essential role of tryptophan 5-hydroxylase, a tetrahydrobiopterin and iron-dependent enzyme. It discusses the conversion of tryptophan to 5-hydroxytryptophan (5-HTP) and its potential to increase serotonin levels, which are linked to mood and sleep regulation. The tutorial also covers the cells that express enzymes for serotonin synthesis, including those in the brain, gut, and pineal gland, and concludes with a recap of key concepts and terms.

What is the consequence of not having tryptophan in the diet?

• Increased serotonin production

• Improved mood regulation

• Deficiency in serotonin

• Excessive melatonin production

Which enzyme is responsible for the hydroxylation of tryptophan?

• Aromatic amino acid decarboxylase

• Tryptophan 5-hydroxylase

• Phenylalanine hydroxylase

• Tyrosine hydroxylase

What is the role of tetrahydrobiopterin in the enzymatic process?

• It acts as a reducing agent

• It is a cofactor for tryptophan 5-hydroxylase

• It is a substrate for serotonin synthesis

• It inhibits the hydroxylation process

What is 5-HTP commonly used for?

• To enhance tryptophan absorption

• To inhibit melatonin synthesis

• To increase serotonin production

• To decrease serotonin levels

Which cells are known to synthesize serotonin?

• Liver cells

• Muscle cells

• Intestinal cells

• Bone cells

What is the final product of the decarboxylation of 5-HTP?

• Melatonin

• Tryptophan

• Serotonin

• Dopamine

What is the abbreviation for serotonin?

• 5-Hydroxytryptamine

• 5-Hydroxytryptophan

• 5-HT

• 5-HTP