Creutzfeldt-Jakob Disease (CJD): An Overview of Symptoms, Causes, & Diagnosis

The video explains the role of proteins in neuron function and introduces Creutzfeldt-Jakob Disease (CJD), a rare prion disease. It describes the symptoms, including rapidly progressive dementia, myoclonus, and ataxia. The video details how prion proteins misfold, leading to cell death, and outlines the four types of CJD: sporadic, familial, iatrogenic, and variant. Diagnosis methods like EEG, MRI, and CSF analysis are discussed, along with the disease's progression and prognosis. The video concludes with a case study of a patient named Anthony, who succumbed to CJD.

What are the key symptoms of Creutzfeldt-Jakob Disease as observed in Anthony?

• Chronic fatigue and fever

• Severe headaches and nausea

• Rapidly progressive dementia and myoclonus

• Memory loss and muscle weakness

What is the primary cause of cell death in Creutzfeldt-Jakob Disease?

• Viral infection

• Bacterial invasion

• Accumulation of misfolded prion proteins

• Genetic mutation

Which type of Creutzfeldt-Jakob Disease is most common?

• Familial CJD

• Iatrogenic CJD

• Variant CJD

• Sporadic CJD

What diagnostic test is used to detect abnormal electric signals in the brain for CJD?

• CT Scan

• EEG Study

• Blood Test

• Ultrasound

Which protein, not a prion, is released into the CSF in people with CJD?

• Amyloid beta

• 1433 protein

• Tau protein

• Synuclein

What is the typical prognosis for individuals diagnosed with Creutzfeldt-Jakob Disease?

• Full recovery within a year

• Death within one year from symptom onset

• Chronic condition with long-term management

• Gradual improvement over several years

What is the final confirmation method for diagnosing CJD after death?

• Genetic testing

• Postmortem autopsy

• Skin biopsy

• Blood test