GABA Biosynthesis and Catabolism

The video explains the synthesis of GABA from glutamate and its role in the central nervous system. It highlights the ineffectiveness of GABA supplements due to their inability to cross the blood-brain barrier and the endogenous production of GABA by neurons. The video also covers the metabolic pathway of GABA degradation, which involves conversion into succinate for entry into the TCA cycle, and discusses the compartmentalization of GABA metabolism within neurons.

What is the enzyme responsible for converting glutamate to GABA?

• Gamma transaminase

• Glutaminase

• Glutamate decarboxylase

• Succinate dehydrogenase

Why are GABA supplements ineffective in relaxing the brain?

• They are not absorbed in the stomach

• They are broken down before reaching the brain

• GABA is synthesized endogenously in the brain

• They cause adverse side effects

What prevents GABA from crossing the blood-brain barrier?

• Its rapid metabolism

• Its large molecular size

• Its polar nature

• Its hydrophobic nature

Which enzyme converts GABA into succinate semi-aldehyde?

• Glutaminase

• Succinate dehydrogenase

• Gamma transaminase

• Glutamate decarboxylase

What is the final product of GABA degradation that enters the TCA cycle?

• Fumarate

• Alpha-ketoglutarate

• Succinate

• Citrate

Where does the synthesis of GABA primarily occur within the neuron?

• Mitochondria

• Cytosol

• Nucleus

• Endoplasmic reticulum

In which cellular compartment does the degradation of GABA take place?

• Mitochondria

• Golgi apparatus

• Nucleus

• Cytosol