Lipid Biosynthesis Mechanism of Statins & Inhibiting CoQ Synthesis

The video explains the action of statin medications, which reduce cholesterol synthesis by inhibiting the enzyme HMG CoA reductase. It details the cholesterol biosynthesis pathway, highlighting the role of isoprenoids and Coenzyme Q. Statins lower cholesterol but also reduce Coenzyme Q and vitamin D synthesis, potentially affecting the electron transport chain. Supplementation with Coenzyme Q and vitamin D is advised for those on statins.

What is the primary action of statin medications in the body?

• Enhance dietary cholesterol absorption

• Increase cholesterol synthesis

• Decrease cholesterol synthesis

• Convert cholesterol to bile acids

Which enzyme is inhibited by statins to reduce cholesterol synthesis?

• HMG CoA synthase

• HMG CoA lyase

• HMG CoA reductase

• Acetyl CoA carboxylase

What is the role of Acetyl CoA in cholesterol synthesis?

• It inhibits HMG CoA reductase

• It is a precursor for mevalonate

• It is converted into ketone bodies

• It is used to synthesize bile acids

Which of the following is NOT a product of isoprenoid pathways?

• Glucose

• Cholesterol

• Vitamin D

• Coenzyme Q

Why might individuals on statins be advised to take Coenzyme Q supplements?

• To increase cholesterol levels

• To enhance bile acid production

• To support the electron transport chain

• To boost vitamin D synthesis

What is a potential side effect of statin use related to vitamin D?

• Conversion of vitamin D to cholesterol

• No effect on vitamin D

• Decreased vitamin D synthesis

• Increased vitamin D synthesis

What is the committed step in cholesterol synthesis that statins inhibit?

• Conversion of Acetyl CoA to HMG CoA

• Conversion of squalene to cholesterol

• Conversion of HMG CoA to mevalonate

• Conversion of mevalonate to isoprenoids