Glycogen Synthase Mechanism

The video tutorial explains the process of glycogen synthesis, focusing on the role of glycogen synthase and UDP-glucose. It describes the mechanism of chain lengthening through SN2 reactions, involving the catalytic action of glutamate. The tutorial also covers the formation of A1 to 4 linkages and the significance of alpha confirmation in glycogen structure.

What is the primary role of glycogen synthase in glycogen synthesis?

• To break down glucose units

• To convert glucose into fructose

• To inhibit the synthesis of glycogen

• To lengthen the glucose chain by one unit

What is the function of UDP glucose in glycogen synthesis?

• It converts glucose to glycogen

• It acts as a glucose donor

• It inhibits glycogen synthase

• It breaks down glycogen

Which type of reaction mechanism is involved in the action of the catalytic glutamate residue during glycogen synthesis?

• SN1 reaction

• E1 reaction

• SN2 reaction

• E2 reaction

What is the significance of the A1 to 4 linkages in glycogen?

• They allow glycogen to dissolve in water

• They provide structural stability to glycogen

• They enable glycogen to be stored in the liver

• They facilitate the breakdown of glycogen

How is the alpha configuration of the anomeric carbon determined in glycogen?

• By the activity of glycogen synthase

• By the length of the glucose chain

• By the direction of the C H2O group

• By the presence of UDP glucose