Von Willebrand Disease | Pathophysiology, Types, Symptoms and Treatment

The video provides a comprehensive overview of Von Willebrand disease, the most common inherited bleeding disorder. It explains the role of Von Willebrand factor (VWF) in hemostasis, platelet aggregation, and adhesion. The video discusses the clinical features, types, and genetic inheritance patterns of the disease. It also covers diagnostic methods, the impact of blood type, and treatment options, including desmopressin and factor VIII transfusions. Additionally, the video addresses acquired Von Willebrand disease and its association with conditions like aortic stenosis and Wilms tumor.

What is the primary cause of von Willebrand disease?

• Deficiency of Factor X

• Deficiency of von Willebrand factor

• Deficiency of Factor IX

• Excessive platelet production

Which chromosome is the von Willebrand factor gene located on?

• Chromosome 12

• Chromosome 21

• Chromosome 7

• Chromosome 18

What is one of the key roles of von Willebrand factor in hemostasis?

• Inhibiting platelet aggregation

• Increasing red blood cell production

• Promoting platelet aggregation and adhesion

• Reducing blood viscosity

Which of the following is a common clinical feature of von Willebrand disease?

• High blood pressure

• Severe joint bleeding

• Mucocutaneous bleeding

• Excessive clotting

What distinguishes Type 3 von Willebrand disease from other types?

• It is inherited in an autosomal dominant manner

• It only affects males

• It involves a total absence of von Willebrand factor

• It is the most common type

Which subtype of Type 2 von Willebrand disease is characterized by hyperfunctional platelet binding?

• Type 2M

• Type 2N

• Type 2B

• Type 2A

What is a common diagnostic test for von Willebrand disease?

• Kidney function test

• Liver function test

• Complete blood count (CBC)

• Electrocardiogram (ECG)

Which treatment is commonly used for less severe cases of von Willebrand disease?

• Heparin

• Aspirin

• Desmopressin (DDAVP)

• Warfarin

How does blood type affect von Willebrand disease?

• Type O blood has higher levels of von Willebrand factor

• Type AB blood has lower levels of von Willebrand factor

• Blood type has no effect on von Willebrand factor levels

• Type O blood has lower levels of von Willebrand factor

What is the role of desmopressin in treating von Willebrand disease?

• It increases red blood cell production

• It decreases platelet count

• It induces the release of von Willebrand factor and factor 8

• It inhibits von Willebrand factor activity