Glycolysis Allostery

The video tutorial explains the allosteric control of glycolysis, focusing on three key enzymes: hexokinase, phosphofructokinase, and pyruvate kinase. It discusses how energy charge influences glycolysis, with high energy molecules like ATP and NADH inhibiting the process, while low energy molecules like ADP and AMP activate it. The tutorial also covers the role of allosteric activators and inhibitors in regulating these enzymes, and introduces gluconeogenesis as the reverse process of glycolysis.

Which enzyme is responsible for converting glucose to glucose 6-phosphate in glycolysis?

• Phosphofructokinase

• Hexokinase

• Pyruvate kinase

• Glyceraldehyde 3-phosphate dehydrogenase

What happens to glycolysis when ATP and NADH levels are high?

• Glycolysis speeds up

• Glycolysis remains unchanged

• Glycolysis converts to gluconeogenesis

• Glycolysis slows down

Which of the following is a low energy charge molecule?

• ATP

• NADH

• ADP

• Glucose 6-phosphate

What is the role of phosphate in the regulation of hexokinase?

• It inhibits hexokinase

• It activates hexokinase

• It has no effect on hexokinase

• It converts hexokinase to another enzyme

Which molecule acts as an allosteric inhibitor of phosphofructokinase?

• ADP

• AMP

• ATP

• Phosphate

What is the main regulatory enzyme of glycolysis?

• Pyruvate kinase

• Phosphofructokinase

• Glyceraldehyde 3-phosphate dehydrogenase

• Hexokinase

Which molecule is an allosteric activator of pyruvate kinase?

• ATP

• ADP

• Citrate

• NADH

How does NADH affect pyruvate kinase?

• It converts pyruvate kinase to another enzyme

• It has no effect on pyruvate kinase

• It inhibits pyruvate kinase

• It activates pyruvate kinase

What process is promoted when glycolysis enzymes are inhibited?

• Photosynthesis

• Fermentation

• Gluconeogenesis

• Glycolysis

Which enzyme is not directly involved in the regulation of glycolysis?

• Hexokinase

• Pyruvate kinase

• Phosphofructokinase

• Isocitrate dehydrogenase