PUFAs: Beta-Oxidation of Linoleic Acid (2 Double Bonds)

The video tutorial explains the metabolism of fatty acids, focusing on linoleic acid and its role in energy production. It details the beta oxidation process, highlighting the importance of trans double bonds and the role of specific enzymes. The tutorial also discusses the selectivity of beta oxidation for different types of fatty acids, emphasizing the metabolic challenges posed by polyunsaturated fatty acids with multiple double bonds.

Which type of fatty acid is linoleic acid?

• Omega-3 fatty acid

• Omega-6 fatty acid

• Trans fatty acid

• Saturated fatty acid

What is required for beta oxidation to occur?

• A cis 2-3 double bond

• A 4-5 double bond

• A trans 2-3 double bond

• A 3-4 double bond

Which enzyme is responsible for converting a 3-4 trans double bond into a 2-3 trans double bond?

• Fatty acyl CoA dehydrogenase

• Enoyl CoA isomerase

• Dienyl CoA reductase

• Hydratase

What is the role of 2,4-dienoyl CoA reductase in fatty acid metabolism?

• It removes a double bond

• It isomerizes double bonds

• It adds a double bond

• It reduces conjugated double bonds

Why are polyunsaturated fatty acids with three or more double bonds not typically metabolized for energy?

• They are not found in the body

• They are already saturated

• They are too large

• They require too much NADPH

Which fatty acid is known to be pro-inflammatory?

• DHA

• EPA

• Arachidonic acid

• Linoleic acid

What is the significance of the balance between arachidonic acid and EPA/DHA?

• It regulates blood sugar

• It determines the energy level

• It affects the inflammatory state

• It influences fat storage