The Curious History of the Lab Rat

For nearly 200 years, rats have been central to scientific research, though they are now surpassed by mice. Rats, particularly the Norwegian brown rat, were initially used due to their rapid growth and ease of breeding. Albino rats became popular in labs, leading to the development of standardized strains like the Worcester rat. Despite the rise of lab mice, rats remain crucial for research, especially in studying complex brain functions and diseases. Their genetic similarity to humans makes them valuable for cancer and neurological research.

What has been the trend in the use of rats versus mice in scientific research over the past 20 years?

• Mice have surpassed rats in usage.

• Both rats and mice are used equally.

• Rats have become more popular than mice.

• Neither rats nor mice are used anymore.

Why were albino rats initially separated from other rats in the 1800s?

• They were used for food.

• They were more resistant to diseases.

• They were easier to identify for breeding.

• They were considered more aggressive.

What was the significance of the Worcester rat in scientific research?

• It was the first rat to be genetically modified.

• It was the first rat used in cancer research.

• It was the first animal bred solely for research.

• It was the first rat used in space experiments.

Why are rats still important in research despite the rise of mice?

• Rats are cheaper to maintain.

• Rats have more complex brains than mice.

• Rats are more resistant to diseases.

• Rats are easier to genetically modify.

What percentage of human genes related to diseases are shared with rats?

• 50%

• Almost all

• 70%

• 85%