Ubiquitination of Damaged Proteins

Ubiquitination of Damaged Proteins

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Science, Chemistry, Biology, Engineering

University

Hard

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The video explains the ubiquitination process, where damaged proteins are tagged with ubiquitin for degradation. It details the roles of E1, E2, and E3 enzymes in transferring ubiquitin to lysine residues on proteins, forming an amide bond. The process requires ATP to facilitate energy transitions. Polyubiquitination signals the cell to degrade the protein using a proteasome, recycling amino acids for new protein synthesis.

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7 questions

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1.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the primary function of ubiquitination in cells?

To increase protein stability

To enhance protein synthesis

To signal the degradation of damaged proteins

To facilitate protein folding

2.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which enzyme is responsible for attaching ubiquitin to the damaged protein?

Proteasome

E3

E2

E1

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the role of E1 in the ubiquitination process?

It activates ubiquitin by attaching an adenosine monophosphate

It degrades the ubiquitinated protein

It transports ubiquitin to the proteasome

It directly attaches ubiquitin to the damaged protein

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Why is ATP necessary in the ubiquitination process?

To degrade the ubiquitinated protein

To provide energy for the formation of a thioester bond

To stabilize the ubiquitin molecule

To directly attach ubiquitin to lysine residues

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is polyubiquitination?

The attachment of multiple ubiquitin molecules to a protein

The degradation of ubiquitin molecules

The attachment of a single ubiquitin molecule to a protein

The removal of ubiquitin from a protein

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the role of the proteasome in the cell?

To synthesize new proteins

To transport proteins across the cell membrane

To attach ubiquitin to proteins

To degrade polyubiquitinated proteins

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What happens to the amino acids after a protein is degraded by the proteasome?

They are used to produce energy

They are stored in the cell

They are excreted from the cell

They are recycled to build new proteins