You’re Not a Lab Mouse, but You Might Be a Wild Mouse

The video discusses the limitations of using inbred lab mice for health research, particularly in immune system studies. It highlights the genetic uniformity of lab mice, which makes them less representative of human biology. Wild mice, with their genetic diversity and exposure to various pathogens, offer more human-like immune responses. Researchers are exploring new models like the Collaborative Cross and Diversity Outbred mice to bridge the gap between lab mice and humans, aiming for more accurate and applicable research outcomes.

Why are lab mice often used in research despite their limitations?

• They have diverse genetic backgrounds.

• Their genetic makeup is well understood.

• They have strong immune systems.

• They are easy to breed and maintain.

What is a significant difference between wild mice and lab mice?

• Wild mice have uniform genetic makeup.

• Lab mice have more diverse immune responses.

• Wild mice have more genetic variation.

• Lab mice are exposed to more environmental factors.

What is a key benefit of using wild mice in lab experiments?

• They offer more human-like immune responses.

• They have a longer lifespan.

• They require less maintenance.

• They are easier to control.

How do wild mice help improve the relevance of research findings?

• By being easier to handle in labs.

• By providing a more controlled environment.

• By having a shorter lifespan.

• By offering genetic diversity similar to humans.

What is the Collaborative Cross initiative?

• A method to create genetically identical mice.

• A program to eliminate genetic variation in mice.

• A breeding program for lab mice only.

• A breeding initiative combining lab and wild mice.

What is the purpose of diversity outbred mice in research?

• To increase the lifespan of lab mice.

• To simplify the breeding process.

• To provide a more representative genetic sample.

• To reduce the cost of experiments.

How do diversity outbred mice contribute to cancer research?

• By eliminating the need for lab mice.

• By reducing the need for human trials.

• By increasing the speed of research.

• By providing consistent genetic markers.