Creatine Function (2/2): Degradation to Creatinine

The video explains the degradation of creatine and phosphocreatine into creatinine, a nonenzymatic process. Phosphocreatine cyclizes more readily than creatine. Creatinine is excreted via the kidneys. Creatine is replenished through synthesis or diet, with 50% synthesized de novo. Creatine supplementation is proven to enhance phosphocreatine stores, aiding high-intensity exercise.

What is the primary product formed when creatine and phosphocreatine undergo spontaneous cyclization?

• Ammonia

• Urea

• Creatinine

• Lactic acid

Which organ is primarily responsible for excreting creatinine from the body?

• Kidney

• Liver

• Heart

• Lungs

What percentage of creatine in the average person is synthesized de novo?

• 25%

• 50%

• 75%

• 100%

How does creatine supplementation affect phosphocreatine stores in the body?

• Decreases them

• Has no effect

• Increases them

• Converts them to creatinine

What type of exercise is most likely to benefit from increased phosphocreatine stores due to creatine supplementation?

• Powerlifting

• Yoga

• Swimming

• Long-distance running