Macroautophagy | Transcriptional Regulation: Lesson 2

The video discusses transcriptional regulation of macroautophagy, focusing on transcriptional repressors like Zach Scan 3, HSF1, TCF4, XBP1, FXR, and NF Kappa B. Each repressor's role in either suppressing or enhancing macroautophagy is explained, highlighting their interactions with various proteins and pathways. The video emphasizes the dual functions of some repressors, such as XBP1 and NF Kappa B, in both upregulating and downregulating specific proteins, impacting the macroautophagy pathway.

Which transcriptional repressor is known to enter the nucleus during the fed state to suppress macroautophagy?

• XBP1

• TCF4

• Zaktan 3

• HSF1

What is the primary effect of HSF1 on P62 expression?

• It stabilizes P62

• It has no effect on P62

• It downregulates P62

• It upregulates P62

How does TCF4 regulate P62 expression?

• By upregulating P62

• By downregulating P62

• By stabilizing P62

• By degrading P62

What dual role does XBP1 play in the macroautophagy pathway?

• It has no effect on proteins

• It both upregulates and downregulates proteins

• It only downregulates proteins

• It only upregulates proteins

Which transcriptional repressor is considered the opposite of PPAR Alpha?

• FXR

• Zaktan 3

• HSF1

• NF Kappa B

What effect does NF Kappa B have on beclin 1?

• It stabilizes beclin 1

• It downregulates beclin 1

• It degrades beclin 1

• It upregulates beclin 1

Which transcriptional repressor can inhibit E2F1, affecting macroautophagy?

• FXR

• NF Kappa B

• XBP1

• HSF1