Polycythemia Rubra Vera | Pathophysiology, Symptoms, Diagnosis and Treatment

The video tutorial provides a comprehensive overview of Polycythemia Rubra Vera (PRV), a clonal pluripotent stem cell disorder leading to increased red blood cell production. It covers the pathophysiology, including the JAK2 gene mutation, and its effects on blood volume and viscosity. The tutorial details blood findings, signs, and symptoms such as erythromelalgia and hypertension. It explains the WHO criteria for diagnosis and discusses treatment options like phlebotomy and JAK2 inhibitors.

What is another name for Polycythemia Rubra Vera?

• Sickle Cell Anemia

• Malady de Vaquez

• Hemophilia

• Thalassemia

Which gene mutation is commonly associated with PRV?

• EGFR

• TP53

• BRCA1

• JAK2

What is the typical median hemoglobin level in PRV patients?

• 184 grams per liter

• 200 grams per liter

• 150 grams per liter

• 120 grams per liter

Which of the following is a common symptom of PRV?

• Cough

• Erythromelalgia

• Nausea

• Blurred vision

What is a major risk factor for thrombosis in PRV patients?

• Increased platelet count

• Low blood pressure

• Dehydration

• Vitamin deficiency

According to WHO criteria, what is a major diagnostic criterion for PRV?

• Low white blood cell count

• Presence of JAK2 mutation

• High cholesterol levels

• Low platelet count

What is the target hematocrit level in PRV treatment through phlebotomy?

• Less than 35%

• Less than 40%

• Less than 45%

• Less than 50%

Which medication is used to reduce thrombosis risk in PRV patients?

• Naproxen

• Paracetamol

• Ibuprofen

• Aspirin (ASA)

What is the role of hydroxyurea in PRV treatment?

• To increase platelet count

• To decrease red blood cell production

• To reduce white blood cell count

• To increase red blood cell production

Which of the following is a JAK2 inhibitor used in PRV treatment?

• Nilotinib

• Dasatinib

• Imatinib

• Ruxolitinib