Homotopic, Enantiotopic, Diastereotipic, and Heterotopic Protons

The video tutorial by Professor Dave explains key terms in NMR spectroscopy: homotopic, enantiotopic, diastereotopic, and heterotopic. Using examples like ethane, butane, and nitrobenzene, the video illustrates how these terms describe the relationships between protons in molecules. It also covers how these relationships affect chemical shifts in NMR spectra, aiding in the interpretation of molecular structures. The tutorial concludes with an analysis of a complex molecule to demonstrate the application of these concepts.

What is the relationship between two protons in ethane when replaced with chlorine, resulting in the same molecule?

• Enantiotopic

• Diastereotopic

• Homotopic

• Heterotopic

In the context of butane, what relationship is formed when protons are replaced with chlorine, creating enantiomers?

• Heterotopic

• Homotopic

• Diastereotopic

• Enantiotopic

What is the key difference in diastereotopic protons compared to enantiotopic protons?

• They create structural isomers

• They form the same molecule

• They have identical chemical shifts

• They involve a pre-existing stereocenter

When protons in nitrobenzene are replaced, resulting in structural isomers, what is their relationship?

• Homotopic

• Enantiotopic

• Diastereotopic

• Heterotopic

Which type of protons will show the same chemical shift in an NMR spectrum?

• Homotopic and Enantiotopic

• Diastereotopic and Heterotopic

• Only Homotopic

• Only Heterotopic

What happens to the chemical shift of diastereotopic protons in an NMR spectrum?

• They show the same chemical shift

• They show a different chemical shift

• They do not appear on the spectrum

• They merge with heterotopic protons

In a molecule with a chiral center, what relationship do protons have if replacing them results in diastereomers?

• Homotopic

• Enantiotopic

• Heterotopic

• Diastereotopic