P450 Metabolism | First Pass Effect & Phases 1/2 Metabolism

The video tutorial explains drug metabolism, focusing on the first pass effect and phase one and two metabolism. It describes how orally taken drugs are absorbed through the GI tract, enter the hepatic portal vein, and reach the liver. The liver acts as a checkpoint, where some drugs are metabolized into inactive forms before entering general circulation. The tutorial details the chemical modifications in phase one and two metabolism, highlighting the role of cytochrome P-450 enzymes. Finally, it discusses drug elimination through feces and urine, emphasizing the importance of making drugs more polar for excretion.

How do phase one and phase two metabolism differ in their processes?

What is the significance of making drugs more polar during metabolism?

What are the major routes of elimination for drugs from the body?

Describe the enterohepatic circulation and its role in drug elimination.